One of the significant naturally occurring short-circuits in the chemiosmotic process is manifest through the activity of uncoupling protein 1, most notably present in the inner membrane of mitochondria in brown adipose tissue. Much has been learnt about the mechanism of action of uncoupling protein 1 since its discovery in the 1970's, yet many areas of controversy surround (i) the mechanism of its action, (ii) novel regulators of its activity, and (iii) the tissue specificity of its expression. In this mini-review, areas of controversy are highlighted from the aforementioned categories using selected key experiments to demonstrate the arguments.

中文翻译：

---

解偶联蛋白1：化学渗透过程中的短路。

化学结合过程中自然发生的重大短路之一是通过解偶联蛋白1的活性表现出来的，最明显的是存在于棕色脂肪组织线粒体内膜中。自1970年代发现解偶联蛋白1的作用机理以来，人们已学到了很多东西，但许多争议领域围绕着（i）其作用机理，（ii）其活性的新型调节剂和（iii）组织其表达的特异性。在此小型审查中，使用选定的关键实验从论证类别中突出了争议领域，以论证论点。