The nuclear factor-kappaB (NF-kappaB) pathway is one of the most important cellular signal transduction pathways involved in both physiologic processes and disease conditions. It plays important roles in the control of immune function, inflammation, stress response, differentiation, apoptosis, and cell survival. Moreover, NF-kappaB is critically involved in the processes of development and progression of cancers. More importantly, recent studies have shown that NF-kappaB signaling also plays critical roles in the epithelial-mesenchymal transition (EMT) and cancer stem cells. Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases.

中文翻译：

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NF-κB信号通路及其在人类疾病中的治疗意义。

核因子-κB（NF-kappaB）途径是参与生理过程和疾病状况的最重要的细胞信号转导途径之一。它在控制免疫功能，炎症，应激反应，分化，凋亡和细胞存活中起重要作用。此外，NF-kappaB至关重要地参与了癌症的发展和进程。更重要的是，最近的研究表明，NF-κB信号在上皮-间质转化（EMT）和癌症干细胞中也起着关键作用。因此，靶向NF-κB信号通路可能是预防和/或治疗人类癌症和炎性疾病的有效策略。