Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem particularly suited for fine-tuning neuronal properties and responses because of their remarkably large and variable repertoire of functions, enabling integration of a wide range of cellular signals. Here, we discuss the involvement of HCN channels in cortical and hippocampal network maturation, and consider potential roles of developmental HCN channel dysregulation in brain disorders such as epilepsy.

中文翻译：

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超极化激活发育中的神经元网络中的环核苷酸门控（HCN）通道。


发育中的神经网络不断进化，要求神经元调节其内在特性及其对传入突触信号的反应。新的证据支持超极化激活的环核苷酸门控（HCN）通道在这种神经元可塑性中的作用。 HCN 通道似乎特别适合微调神经元特性和反应，因为它们的功能非常庞大且可变，能够整合各种细胞信号。在这里，我们讨论 HCN 通道在皮质和海马网络成熟中的参与，并考虑发育性 HCN 通道失调在癫痫等脑部疾病中的潜在作用。