A series of 2‐sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti‐inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab–d and 6Be displayed an interesting analgesic profile in the acetic acid‐induced abdominal contractions test. Based on the results of the carrageenan‐hind paw edema test, compound 6Af showed potential anti‐inflammatory activity.

中文翻译：

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2-磺酰亚氨基二氢嘧啶：一类新型镇痛化合物

已经合成了一系列 2-磺酰亚氨基二氢嘧啶衍生物，并在体内评估了它们的镇痛和抗炎活性。将结果与乙酰水杨酸的结果进行比较。化合物 6Ab-d 和 6Be 在醋酸诱导的腹部收缩试验中显示出有趣的镇痛特性。根据角叉菜胶-后爪水肿试验的结果，化合物 6Af 显示出潜在的抗炎活性。