We describe a prospective strategy for reading the encyclopedic information encoded in the genome: using a nanopore in a membrane formed from a metal-oxide semiconductor (MOS)-capacitor to sense the charge in deoxyribonucleic acid (DNA). In principle, as DNA permeates the capacitor-membrane through the pore, the electrostatic charge distribution characteristic of the molecule should polarize the capacitor and induce a voltage on the electrodes that can be measured. Silicon nanofabrication and molecular dynamic simulations with atomic detail are technological linchpins in the development of this detector. The sub-nanometer precision available through silicon nanotechnology facilitates the fabrication of the detector, and molecular dynamics provides us with a means to design it and analyze the experimental outcomes.

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超越基因芯片

我们描述了一种读取基因组中编码的百科全书信息的前瞻性策略：使用由金属氧化物半导体 (MOS) 电容器形成的膜中的纳米孔来感应脱氧核糖核酸 (DNA) 中的电荷。原则上，当 DNA 通过孔渗透到电容器膜时，分子的静电荷分布特性应该使电容器极化并在电极上感应出可测量的电压。硅纳米加工和具有原子细节的分子动力学模拟是该探测器开发的技术关键。通过硅纳米技术获得的亚纳米精度促进了探测器的制造，分子动力学为我们提供了一种设计它和分析实验结果的方法。