Exercise dramatically increases oxygen consumption and causes oxidative stress. Superoxide dismutase (SOD) is important in the first-line defence mechanisms against oxidative stress. To investigate the effect of acute exercise on the expression of SOD, we examined the expression of mRNA for three SOD isozymes, in mice run on a treadmill to exhaustion. Six hours after exercise, the expression of extracellular SOD (EC-SOD) mRNA increased significantly in skeletal muscle and persisted for 24 h, whereas no change was observed for cytoplasmic and mitochondrial SOD mRNA. Moreover, acute exercise also induced EC-SOD mRNA in the aorta. These results suggest that a single bout of exercise is enough to augment the expression EC-SOD mRNA in skeletal muscle and the aorta, and may partly explain the beneficial effect of exercise.

中文翻译：

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急性运动会增加骨骼肌和主动脉中细胞外超氧化物歧化酶的表达。

运动会大大增加氧气消耗并引起氧化应激。超氧化物歧化酶（SOD）在针对氧化应激的一线防御机制中很重要。为了研究急性运动对SOD表达的影响，我们检查了跑步机上精疲力竭的小鼠中三种SOD同工酶的mRNA表达。运动后六个小时，骨骼肌中细胞外SOD（EC-SOD）mRNA的表达显着增加并持续24 h，而胞质和线粒体SOD mRNA则未见变化。此外，急性运动还诱导主动脉中的EC-SOD mRNA。这些结果表明，单次运动足以增加骨骼肌和主动脉中EC-SOD mRNA的表达，并且可能部分解释了运动的有益效果。