Phyllanthus amarus Linn is a widely distributed tropical medicinal plant highly valued for its therapeutic properties. The antioxidant activity of some of its principal constituents, namely amariin, 1-galloyl-2,3-dehydrohexahydroxydiphenyl (DHHDP)-glucose, repandusinic acid, geraniin, corilagin, phyllanthusiin D, rutin and quercetin 3-O-glucoside were examined for their ability to scavenge free radicals in a range of systems including 2,2-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azobis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS)/ferrylmyoglobin, ferric reducing antioxidant power (FRAP) and pulse radiolysis. In addition, their ability to protect rat liver mitochondria against oxidative damage was determined by measuring the ROO* radical induced damage to proteins and lipids and *OH radical induced damage to plasmid DNA. The compounds showed significant antioxidant activities with differing efficacy depending on the assays employed. Amariin, repandusinic acid and phyllanthusiin D showed higher antioxidant activity among the ellagitannins and were comparable to the flavonoids, rutin and quercetin 3-O-glucoside.

中文翻译：

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药用植物余甘子（Phyllanthus amarus Linn）的某些多酚成分的抗氧化活性。

yl兰（Phyllanthus amarus Linn）是一种分布广泛的热带药用植物，因其治疗特性而受到高度评价。检查了其主要成分的一部分的抗氧化活性，即阿马里林，1-galloyl-2,3-dehydrohexahydroxydiphenyl（DHHDP）-葡萄糖，Repandusinic acid，香叶素，corilagin，phyllanthusiin D，芦丁和槲皮素3-O-葡萄糖苷的抗氧化活性。清除一系列系统中自由基的能力，包括2,2-二苯基-2-吡啶并肼基（DPPH），2,2-偶氮双-3-乙基苯并噻唑啉-6-磺酸（ABTS）/泛铁血红蛋白，三价铁还原抗氧化剂（FRAP） ）和脉冲辐射分解。此外，通过测量ROO *自由基对蛋白质和脂质的损伤以及* OH自由基对质粒DNA的损伤，可以确定它们保护大鼠肝线粒体免受氧化损伤的能力。根据所使用的测定，化合物显示出显着的抗氧化剂活性，且功效不同。紫mari素，repandusinic酸和phyllanthusiin D在鞣花单宁中显示出较高的抗氧化活性，与黄酮类，芦丁和槲皮素3-O-葡萄糖苷相当。