The aim of the present experiment was to test the effects of a wet preservation of triticale contaminated mainly with deoxynivalenol (DON) with sodium metabisulphite (Na2S2O5, SBS) on growth performance, liver function, clinical-chemical plasma parameters and organ histopathology of piglets. For this purpose both the uncontaminated control triticale and the DON contaminated triticale were included in the piglet diet either untreated (CON, FUS) or SBS-treated (CON-SBS, FUS-SBS) and fed for 28 d starting from weaning. The dietary concentrations of DON and DON sulfonate (DONS), the DON derivative resulting from the SBS treatment, amounted to 0.156, 0.084, 2.312 and 0.275 mg DON per kg CON, CON-SBS, FUS and FUS-SBS diet, and to <0.05, <0.05, <0.05 and 1.841 mg/kg diet, respectively. Feeding the FUS diet significantly reduced the feed intake compared to the other three groups as indicated by the significant interactions between triticale source and SBS treatment when the whole experimental period of 28 d was considered (p = 0.014) while live weight gain and feed to gain ratio remained unaffected. The total plasma protein concentration was significantly depressed due to feeding the contaminated diets whereas SBS treatment exerted an increasing effect at the same time (45.4, 49.5, 40.7 and 46.5 g/l for piglets fed the CON, CON-SBS, FUS and FUS-SBS diet, respectively). The liver function was tested by the 13C-methacetin breath test (MBT) allowing evaluation of the cytochrome P4501A2 activity. MBT results, expressed as cumulative percentage dose recovery after 360 min (cPDR360) revealed a slight stimulation of liver function due to SBS treatment (p = 0.052) (37.5, 39.4, 37.4 and 55.1% for piglets fed the CON, CON-SBS, FUS and FUS-SBS diet, respectively). Liver weight and histopathological scoring were only weakly related to the MBT results. Further histopathological examinations of kidneys, pancreas and heart revealed no treatment effects. It was concluded that the SBS treatment of the contaminated triticale restored the performance of piglets to the level of the piglets fed the control diet while the effects on liver function, clinical-chemical plasma parameters – excepting the protein concentration – and organ histopathology were only marginal.

中文翻译：

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镰刀菌毒素污染的小黑麦，未经处理或用焦亚硫酸钠（Na2S2O5，SBS）处理，对断奶仔猪的影响，特别关注 13C-美沙西丁呼气试验确定的肝功能

本实验的目的是测试湿法保存主要受脱氧雪腐镰刀菌烯醇 (DON) 和焦亚硫酸钠 (Na2S2O5, SBS) 污染的黑小麦对仔猪生长性能、肝功能、临床化学血浆参数和器官组织病理学的影响。为此目的，未受污染的对照小黑麦和受 DON 污染的小黑麦都包括在未经处理（CON、FUS）或经 SBS 处理（CON-SBS、FUS-SBS）的仔猪日粮中，并从断奶开始饲喂 28 天。DON 和 DON 磺酸盐 (DONS)（由 SBS 处理产生的 DON 衍生物）的膳食浓度分别为 0.156、0.084、2.312 和 0.275 mg DON/kg CON、CON-SBS、FUS 和 FUS-SBS 饮食，并且<分别为 0.05、<0.05、<0.05 和 1.841 mg/kg 饮食。与其他三组相比，饲喂 FUS 日粮显着降低了采食量，这由黑小麦来源和 SBS 处理之间的显着相互作用表明，当考虑 28 天的整个实验期时（p = 0.014），同时活增重和饲料增重比例未受影响。由于饲喂受污染的日粮，总血浆蛋白浓度显着降低，而 SBS 处理同时发挥了增加作用（饲喂 CON、CON-SBS、FUS 和 FUS-的仔猪分别为 45.4、49.5、40.7 和 46.5 g/l SBS饮食，分别）。肝功能通过 13C-美沙西丁呼气试验 (MBT) 进行测试，从而可以评估细胞色素 P4501A2 的活性。MBT结果，表示为 360 分钟后的累积剂量恢复百分比 (cPDR360) 显示 SBS 治疗对肝功能有轻微刺激 (p = 0.052)（喂食 CON、CON-SBS、FUS 和 FUS 的仔猪分别为 37.5、39.4、37.4 和 55.1% -SBS 饮食，分别）。肝脏重量和组织病理学评分与 MBT 结果仅微弱相关。肾脏、胰腺和心脏的进一步组织病理学检查显示没有治疗效果。得出的结论是，SBS 处理受污染的小黑麦使仔猪的生产性能恢复到饲喂对照日粮的仔猪的水平，而对肝功能、临床化学血浆参数（蛋白质浓度除外）和器官组织病理学的影响仅微不足道. FUS 和 FUS-SBS 饮食，分别）。肝脏重量和组织病理学评分与 MBT 结果仅微弱相关。肾脏、胰腺和心脏的进一步组织病理学检查显示没有治疗效果。得出的结论是，SBS 处理受污染的小黑麦使仔猪的生产性能恢复到饲喂对照日粮的仔猪的水平，而对肝功能、临床化学血浆参数（蛋白质浓度除外）和器官组织病理学的影响仅微不足道. FUS 和 FUS-SBS 饮食，分别）。肝脏重量和组织病理学评分与 MBT 结果仅微弱相关。肾脏、胰腺和心脏的进一步组织病理学检查显示没有治疗效果。得出的结论是，SBS 处理受污染的小黑麦使仔猪的生产性能恢复到饲喂对照日粮的仔猪的水平，而对肝功能、临床化学血浆参数（蛋白质浓度除外）和器官组织病理学的影响仅微不足道.