Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppressing and tumor promoting effects on epithelial cells. It is unclear what determines when TGF-beta and its signaling pathway act predominantly as a tumor suppressor pathway or as a tumor-promoter pathway and whether TGF-beta can have both classes of effects concurrently on a cell. We investigated the effect of TGF-beta on anoikis in colorectal cancer cell lines sensitive to TGF-beta-mediated growth inhibition to determine if the context of the cells could be one of the factors that would affect whether TGF-beta exerts tumor suppressor or oncogene activity on colon cancer cells. We observed variable effects of TGF-beta on anoikis in these cell lines, even though they all are growth-inhibited by TGF-beta. Thus, we show that TGF-beta has variable effects on anoikis in colon cancer cell lines that likely reflects the effects of concurrent gene mutations in the cancer cells and the activation state of the signaling pathways controlled by these genes.

中文翻译：

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TGF-β 对人结肠直肠癌细胞系的增殖和失巢凋亡具有矛盾和背景依赖性影响。

转化生长因子-β (TGF-β) 是一种多能细胞因子，可以对上皮细胞具有肿瘤抑制和肿瘤促进作用。目前尚不清楚是什么决定了 TGF-β 及其信号通路何时主要作为肿瘤抑制通路或作为肿瘤启动通路起作用，以及 TGF-β 是否可以同时对细胞产生两类影响。我们研究了 TGF-β 对 TGF-β 介导的生长抑制敏感的结直肠癌细胞系中失巢凋亡的影响，以确定细胞的环境是否可能是影响 TGF-β 发挥抑癌基因或致癌基因的因素之一对结肠癌细胞的活性。我们观察到 TGF-β 对这些细胞系中失巢凋亡的可变影响，即使它们都被 TGF-β 抑制生长。因此，