Intracranial saccular and abdominal aortic aneurysms (ISAs and AAAs, respectively) result from different underlying disease processes and exhibit different rupture potentials, yet they share many histopathological and biomechanical characteristics. Moreover, as in other vascular diseases, hemodynamics and wall mechanics play important roles in the natural history and possible treatment of these two types of lesions. The goals of this review are twofold: first, to contrast the biology and mechanics of intracranial and abdominal aortic aneurysms to emphasize that separate advances in our understanding of each disease can aid in our understanding of the other disease, and second, to suggest that research on the biomechanics of aneurysms must embrace a new paradigm for analysis. That is, past biomechanical studies have provided tremendous insight but have progressed along separate lines, focusing on either the hemodynamics or the wall mechanics. We submit that there is a pressing need to couple in a new way the separate advances in vascular biology, medical imaging, and computational biofluid and biosolid mechanics to understand better the mechanobiology, pathophysiology, and treatment of these lesions, which continue to be responsible for significant morbidity and mortality. We refer to this needed new class of computational tools as fluid-solid-growth (FSG) models.

中文翻译：

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颅内和腹主动脉瘤：相似点、差异以及对新型计算模型的需求。


颅内囊状动脉瘤和腹​​主动脉瘤（分别为 ISA 和 AAA）由不同的潜在疾病过程引起，并表现出不同的破裂潜力，但它们具有许多共同的组织病理学和生物力学特征。此外，与其他血管疾病一样，血流动力学和壁力学在这两类病变的自然病程和可能的治疗中发挥着重要作用。这篇综述的目标有两个：首先，对比颅内和腹主动脉瘤的生物学和力学，强调我们对每种疾病的理解的单独进展可以帮助我们理解另一种疾病；其次，建议研究对动脉瘤生物力学的研究必须采用新的分析范式。也就是说，过去的生物力学研究提供了巨大的见解，但沿着不同的方向发展，重点关注血流动力学或壁力学。我们认为，迫切需要以新的方式将血管生物学、医学成像、计算生物流体和生物固体力学的各自进展结合起来，以更好地理解这些病变的机械生物学、病理生理学和治疗，这些病变继续导致显着的发病率和死亡率。我们将这种所需的新型计算工具称为流固生长（FSG）模型。