Sensory experience is critical for the proper development and plasticity of the brain throughout life. Successful adaptation to the environment is necessary for the survival of an organism, and this process requires the translation of specific sensory stimuli into changes in the structure and function of relevant neural circuits. Sensory-evoked activity drives synaptic input onto neurons within these behavioral circuits, initiating membrane depolarization and calcium influx into the cytoplasm. Calcium signaling triggers the molecular mechanisms underlying neuronal adaptation, including the activity-dependent transcriptional programs that drive the synthesis of the effector molecules required for long-term changes in neuronal function. Insight into the signaling pathways between the synapse and the nucleus that translate specific stimuli into altered patterns of connectivity within a circuit provides clues as to how activity-dependent programs of gene expression are coordinated and how disruptions in this process may contribute to disorders of cognitive function.

中文翻译：

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神经元发育、可塑性和疾病中突触和细胞核之间的通讯。


感官体验对于大脑一生的正常发育和可塑性至关重要。成功地适应环境对于生物体的生存是必要的，这个过程需要将特定的感觉刺激转化为相关神经回路结构和功能的变化。感觉诱发的活动驱动突触输入到这些行为回路中的神经元，引发膜去极化和钙流入细胞质。钙信号传导触发神经元适应的分子机制，包括驱动神经元功能长期变化所需的效应分子合成的活动依赖性转录程序。深入了解突触和细胞核之间将特定刺激转化为回路内连接模式改变的信号通路，为了解基因表达的活动依赖性程序如何协调以及该过程的破坏如何导致认知功能障碍提供了线索。 。