The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and Cdh1/Fizzy-related activate the APC/C and confer substrate specificity through complex interactions with both the core APC/C and substrate proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity and occurs in multiple ways: targeted protein degradation, phosphorylation, and direct binding of inhibitory proteins. During the specialized divisions of meiosis, the activity of the APC/C must be modified to achieve proper chromosome segregation. Recent studies show that one way in which APC/C activity is modified is through the use of meiosis-specific APC/C activators. Furthermore, regulation of the APC/C during meiosis is carried out by both mitotic regulators of the APC/C as well as meiosis-specific regulators. Here, we review the regulation of APC/C activators during mitosis and the role and regulation of the APC/C during female meiosis.

中文翻译：

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APC/C 激活剂在有丝分裂和减数分裂中的调节。

后期促进复合物/环状体 (APC/C) 是一种多亚基 E3 泛素连接酶，可在有丝分裂期间触发多种底物的降解。Cdc20/Fizzy 和 Cdh1/Fizzy 相关激活 APC/C 并通过与核心 APC/C 和底物蛋白的复杂相互作用赋予底物特异性。Cdc20 和 Cdh1 的调节对于适当的 APC/C 活性至关重要，并以多种方式发生：靶向蛋白质降解、磷酸化和抑制性蛋白质的直接结合。在减数分裂的专门分裂过程中，必须修改 APC/C 的活性以实现适当的染色体分离。最近的研究表明，改变 APC/C 活性的一种方式是使用减数分裂特异性 APC/C 激活剂。此外，减数分裂过程中 APC/C 的调节由 APC/C 的有丝分裂调节因子和减数分裂特异性调节因子共同完成。在这里，我们回顾了有丝分裂过程中 APC/C 激活剂的调节以及雌性减数分裂过程中 APC/C 的作用和调节。