The immunological synapse was initially defined as a stable cell-cell junction composed of three concentric supramolecular activation clusters (SMACs) enriched in particular components: a central SMAC with clustered antigen receptors and kinases, a peripheral SMAC rich in beta2 integrin adhesion molecule LFA-1, and a distal SMAC marked by a critical tyrosine phosphatase. In the past year the SMACs have each been identified with functional modules of amoeboid motility, and the stability of the immunological synapse has been revealed as a reconfiguration of the motile apparatus from an asymmetric hunting mode, a kinapse, to a symmetric gathering mode, the synapse. The genetic control of this process involves actinomyosin regulators PKCtheta and WASp. Crtam is involved in postsynaptic polarity in early kinapses prior to cell division. It is unlikely that the immune system is unique in using symmetrization to stop migration without inactivating motile machinery.

中文翻译：

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猎人到采集者和返回者：免疫突触和突触是变形虫运动主题的变体。

免疫突触最初定义为稳定的细胞-细胞连接，其由三个富含特定成分的同心超分子活化簇（SMAC）组成：具有簇状抗原受体和激酶的中央SMAC，富含beta2整合素粘附分子LFA-1的外围SMAC。 ，以及远端SMAC，其上带有关键的酪氨酸磷酸酶。在过去的一年中，每个SMACs都被鉴定为具有变形性运动功能模块，并且免疫突触的稳定性已被揭示为能动装置从不对称的狩猎模式（即突触）转变为对称的采集模式（即运动）。突触。此过程的遗传控制涉及放线菌素调节剂PKCtheta和WASp。Crtam在细胞分裂之前的早期运动中参与突触后极性。