Mammalian spermatogenesis is a classic adult stem cell-dependent process, supported by self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs provides a model to better understand adult stem cell biology, and deciphering the mechanisms that control SSC functions may lead to treatment of male infertility and an understanding of the etiology of testicular germ cell tumor formation. Self-renewal of rodent SSCs is greatly influenced by the niche factor glial cell line-derived neurotrophic factor (GDNF). In mouse SSCs, GDNF activation upregulates expression of the transcription factor-encoding genes bcl6b, etv5, and lhx1, which influence SSC self-renewal. Additionally, the non-GDNF-stimulated transcription factors Plzf and Taf4b have been implicated in regulating SSC functions. Together, these molecules are part of a robust gene network controlling SSC fate decisions that may parallel the regulatory networks in other adult stem cell populations.

中文翻译：

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哺乳动物精原干细胞自我更新的调节。

哺乳动物精子发生是一种经典的成人干细胞依赖性过程，由精原干细胞 (SSC) 的自我更新和分化支持。研究 SSC 提供了一个模型，可以更好地了解成体干细胞生物学，破译控制 SSC 功能的机制可能会导致治疗男性不育和了解睾丸生殖细胞肿瘤形成的病因。啮齿动物 SSC 的自我更新受生态位因子神经胶质细胞系衍生神经营养因子 (GDNF) 的影响很大。在小鼠 SSC 中，GDNF 激活上调转录因子编码基因 bcl6b、etv5 和 lhx1 的表达，这些基因影响 SSC 自我更新。此外，非 GDNF 刺激的转录因子 Plzf 和 Taf4b 与调节 SSC 功能有关。一起，