Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins. Here we describe the expression pattern of Wif1 throughout the development of the mouse central nervous system (CNS). Wif1 mRNA can be detected as early as the developmental stage E11, and expression persists to adulthood. In embryonic stages, the level of Wif1 expression was very prominent in several areas including the cerebral cortex, the diencephalon and the midbrain, with the strongest level in the hippocampal plate and the diencephalon. However, after birth, the expression level of Wif1 decreased in the cortex and diencephalon. By adulthood, Wif1 is mainly expressed in the medial habenular nucleus (MHb) in the epithalamus, the mitral layer cells in the olfactory bulb and a few nuclei in the hypothalamus. Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that Wif1 may play an essential role in the spatial and temporal regulation of Wnt signals.

中文翻译：

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Wnt抑制剂因子1（Wif1）在小鼠中枢神经系统发育过程中的表达模式。

Wnt抑制剂因子1（WIF-1）是Wnts分泌蛋白的细胞外拮抗剂。在这里，我们描述了整个小鼠中枢神经系统（CNS）发展过程中Wif1的表达模式。Wif1 mRNA可以在发育阶段E11早期检测到，并且表达一直持续到成年。在胚胎期，Wif1表达水平在包括大脑皮层，间脑和中脑在内的多个区域中非常突出，在海马板和中脑中最强。然而，出生后，Wif1在皮层和间脑中的表达水平下降。到成年时，Wif1主要表达在上丘脑的内侧ha状核（MHb），嗅球中的二尖瓣层细胞和下丘脑的几个核中。