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Treatment with granulocyte colony stimulating factor is associated with improvement in endothelial function.
Growth Factors ( IF 1.8 ) Pub Date : 2008-06-24 , DOI: 10.1080/08977190802090614
Ignatios Ikonomidis 1 , Christos Papadimitriou , Georgia Vamvakou , Paraskevi Katsichti , Kiriaki Venetsanou , Kimon Stamatelopoulos , Christos Papamichael , Athanasios-Meletios Dimopoulos , John Lekakis
Affiliation  

PRIMARY OBJECTIVE Granulocyte-colony stimulating factor (G-CSF) is used for the mobilization of bone marrow and endothelial progenitor cells, though G-CSF-induced inflammation may cause endothelial dysfunction. We examined the effects of G-CSF on endothelium, C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha) and anti-inflammatory cytokines namely interleukin 10 (IL-10). RESEARCH DESIGN We studied 60 women with breast cancer, who were randomized to either subcutaneous G-CSF (5 microg/kg), o.d. for 5 days after adjuvant chemotherapy (n = 40) or placebo (n = 20). EXPERIMENTAL INTERVENTIONS We measured flow-mediated dilatation (FMD%) of the brachial artery by ultrasonography, CRP, TNF-alpha, IL-10 and the ratio TNF-alpha/ IL-10 blood levels before, 2-h and 5-days after the G-CSF or placebo treatment. MAIN OUTCOMES AND RESULTS There was a greater increase of FMD, IL-10 and reduction of TNF-alpha/ IL-10, 2 h and 5 days after the G-CSF treatment compared to placebo. Although, CRP and TNF-alpha were higher, TNF-alpha/IL-10 was lower at the end of G-CSF treatment compared to placebo. Improvement of FMD was related to changes of IL-10 and TNF-alpha/IL-10. CONCLUSIONS Treatment with G-CSF improves endothelial function in vivo, possibly by shifting the balance between the pro- and anti-inflammatory cytokines.

中文翻译:

用粒细胞集落刺激因子治疗与内皮功能的改善有关。

原发性粒细胞集落刺激因子(G-CSF)用于动员骨髓和内皮祖细胞,尽管G-CSF诱导的炎症可能引起内皮功能障碍。我们检查了G-CSF对内皮,C反应蛋白(CRP),肿瘤坏死因子-α(TNF-α)和抗炎细胞因子即白介素10(IL-10)的影响。研究设计我们研究了60例乳腺癌患者,这些患者被随机分配到皮下G-CSF(5微克/千克),辅助化疗(n = 40)或安慰剂(n = 20)后od连续5天。实验干预我们通过超声检查,CRP,TNF-α,IL-10以及血浆TNF-α/ IL-10比值在之前,之后2小时和5天后测量肱动脉的血流介导扩张(FMD%) G-CSF或安慰剂治疗。主要结果和结果与安慰剂相比,G-CSF治疗后2小时和5天,FMD,IL-10和TNF-alpha / IL-10的降低更大。尽管CRP和TNF-α较高,但与安慰剂相比,G-CSF治疗结束时TNF-α/ IL-10较低。FMD的改善与IL-10和TNF-α/ IL-10的变化有关。结论用G-CSF治疗可改善体内内皮功能,可能是通过改变促炎和抗炎细胞因子之间的平衡来实现的。
更新日期:2019-11-01
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