The Wnt family of secreted proteins plays a crucial role in nervous system wiring. Wnts regulate neuronal positioning, polarization, axon and dendrite development, and synaptogenesis. These diverse roles of Wnt proteins are due not only to the large numbers of Wnt ligands and receptors but also to their ability to signal through distinct signaling pathways in different cell types and developmental contexts. Studies on Wnts have shed new light on novel molecular mechanisms that control the development of complex neuronal connections. This review discusses recent advances on how Wnt signaling influences different aspects of neuronal circuit assembly through changes in gene expression and/or cytoskeletal modulation.

中文翻译：

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神经回路组装中的 Wnt 信号。

分泌蛋白的 Wnt 家族在神经系统布线中起着至关重要的作用。Wnts 调节神经元定位、极化、轴突和树突发育以及突触发生。Wnt 蛋白的这些不同作用不仅归因于大量的 Wnt 配体和受体，还归因于它们在不同细胞类型和发育环境中通过不同信号通路发出信号的能力。对 Wnt 的研究为控制复杂神经元连接发展的新分子机制提供了新的思路。本综述讨论了 Wnt 信号如何通过基因表达和/或细胞骨架调制的变化影响神经元回路组装的不同方面的最新进展。