Rasmussen syndrome affects previously normal people and forever changes their lives and the lives of their families. Although understood as a probable autoimmune condition, medical treatment remains limited and surgery remains the only cure, although with inevitable functional consequences. Difficulties remain in deciding on the optimal timing of surgery. Here, we review data available to aid clinicians faced with making the decision of when to recommend hemispherectomy. Not all patients have rapidly progressive disease, however, and such patients may benefit from immunomodulatory treatment. Thus, a patient's clinical course requires careful evaluation in order to identify those who would benefit most from early surgery.

中文翻译：

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拉斯穆森综合征的手术时机：耐心是一种美德吗？

拉斯穆森综合征影响以前正常的人，并永远改变他们和家人的生活。尽管被理解为一种可能的自身免疫性疾病，但药物治疗仍然有限，手术仍然是唯一的治疗方法，尽管会带来不可避免的功能后果。在决定最佳手术时机方面仍然存在困难。在这里，我们回顾了可用于帮助临床医生决定何时推荐半球切除术的数据。然而，并非所有患者的疾病进展迅速，这些患者可能受益于免疫调节治疗。因此，患者的临床病程需要仔细评估，以确定哪些人将从早期手术中获益最多。