To develop novel tumor cell microenvironment stimuli-responsive smart controlled-release delivery systems is one of the current common interests of materials science and clinical medicine. Meanwhile, mesoporous silica nanoparticles as a promising drug carrier have become the new area of interest in the field of biomedical application in recent years because of their unique characteristics and abilities to efficiently and specifically entrap cargo molecules. This review describes the more recent developments and achievements of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled-release systems that are able to respond to tumor cell environmental changes, such as pH, glucose, adenosine-5'-triphosphate (ATP), glutathione (GSH), and H(2)O(2).

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基于介孔二氧化硅纳米粒子的细胞微环境刺激响应控释递送系统

开发新型肿瘤细胞微环境刺激响应型智能控释给药系统是当前材料科学和临床医学的共同兴趣之一。同时，介孔二氧化硅纳米粒子作为一种很有前途的药物载体，由于其独特的特性和高效、特异性地捕获货物分子的能力，已成为近年来生物医学应用领域的新热点。这篇综述描述了介孔二氧化硅纳米粒子在药物输送中的最新发展和成就。特别是，我们专注于能够响应肿瘤细胞环境变化的刺激响应控释系统，例如 pH、葡萄糖、腺苷-5'-三磷酸 (ATP)、谷胱甘肽 (GSH) 和 H(2 )O(2)。