The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell interactions, effect of interstitial flow on tumor migration and the role of vascular barrier function. To account for the multi-scale nature of cancer growth and invasion, macroscale models are also necessary. The consideration of fluid dynamics within tumor models at both the micro- and macroscopic levels may greatly improve our ability to more fully mimic the tumor microenvironment.

中文翻译：

---

组织工程可灌注癌症模型。

流体流动对癌症进展的影响目前还不是很清楚，这突出了灌注肿瘤模型来弥合这一知识差距的必要性。使细胞水平的生物过程能够以高时空控制建模，微流体肿瘤模型已证明适用于研究细胞间相互作用、间质流动对肿瘤迁移的影响和血管屏障功能的作用的平台。为了解释癌症生长和侵袭的多尺度性质，宏观模型也是必要的。在微观和宏观层面考虑肿瘤模型中的流体动力学可能会大大提高我们更充分地模拟肿瘤微环境的能力。