Curcumin, a dietary pigment from the plant Curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines. The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral application. Therefore, great efforts were undertaken to enhance the effectiveness of curcumin. Recently, it was demonstrated that curcumin offers the described effects also at low concentrations (0.2-1 μg/ml) when applied in combination with UVA or visible light. The efficacy of this combination was shown in human epidermal keratinocytes and in a panel of other cell species in vitro as well as in a xenograft tumor model with A431 tumor cells injected subcutaneously in the flanks of NMRI nude mice in vivo. The treatment of keratinocytes with curcumin and light resulted in the inhibition of cell growth, and in the induction of apoptosis, whereas no toxic cell membrane damage was detectable. The treatment of tumor bearing nude mice with curcumin and visible light resulted in reduced tumor volumes, reduced proliferation rates, and the induction of apoptosis in the tumors. On the molecular level inhibition of extracellular regulated kinases 1/2 and epidermal growth factor receptor was observed which may aid to inhibition of proliferation and induction of apoptosis. This review covers the experiences of the new combination treatment of human tumors.

中文翻译：

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可见光和/或 UVA 可强烈增强姜黄素的抗肿瘤作用。

姜黄素是一种来自姜黄植物的膳食色素，可抑制细胞增殖并诱导不同细胞系的细胞凋亡。透皮或口服应用后吸收非常低，阻碍了治疗效果。因此，人们付出了巨大的努力来提高姜黄素的有效性。最近，证明姜黄素在与 UVA 或可见光结合使用时，在低浓度 (0.2-1 μg/ml) 下也能提供所描述的效果。这种组合的功效在人表皮角质形成细胞和一组其他细胞种类的体外以及异种移植肿瘤模型中显示，其中 A431 肿瘤细胞在体内皮下注射到 NMRI 裸鼠的侧翼。用姜黄素和光处理角质形成细胞导致细胞生长受到抑制，并且在诱导细胞凋亡中，而未检测到毒性细胞膜损伤。用姜黄素和可见光治疗荷瘤裸鼠导致肿瘤体积减小、增殖率降低并诱导肿瘤细胞凋亡。在分子水平上观察到细胞外调节激酶 1/2 和表皮生长因子受体的抑制作用，这可能有助于抑制增殖和诱导细胞凋亡。这篇综述涵盖了人类肿瘤新联合治疗的经验。在分子水平上观察到细胞外调节激酶 1/2 和表皮生长因子受体的抑制作用，这可能有助于抑制增殖和诱导细胞凋亡。本综述涵盖了人类肿瘤新联合治疗的经验。在分子水平上观察到细胞外调节激酶 1/2 和表皮生长因子受体的抑制作用，这可能有助于抑制增殖和诱导细胞凋亡。本综述涵盖了人类肿瘤新联合治疗的经验。