This article reviews recent advances achieved during recent years on various aspects of antibody humanization theories and techniques. Common methods for producing humanized antibodies including framework-homology-based humanization, germline humanization, complementary determining regions (CDR)-homology-based humanization and specificity determining residues (SDR) grafting, as well as advantages and disadvantages of each of these methods and their applications are discussed.

中文翻译：

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抗体人性化方法-审查和更新。

本文回顾了近年来在抗体人源化理论和技术的各个方面取得的最新进展。产生人源化抗体的常用方法包括基于框架同源性的人源化，种系人源化，互补决定区（CDR）-基于同源性的人源化和特异性决定残基（SDR）嫁接，以及每种方法及其优点和缺点讨论了应用程序。