Continuous glucose monitoring (CGM) sensors based on affinity detection are desirable for long-term and stable glucose management. However, most affinity sensors contain mechanical moving structures and complex design in sensor actuation and signal readout, limiting their reliability in subcutaneously implantable glucose detection. We have previously demonstrated a proof-of-concept dielectric glucose sensor that measured pre-mixed glucose-sensitive polymer solutions at various glucose concentrations. This sensor features simplicity in sensor design, and possesses high specificity and accuracy in glucose detection. However, lack of glucose diffusion passage, this device is unable to fulfill real-time in-vivo monitoring. As a major improvement to this device, we present in this paper a fully implantable MEMS dielectric affinity glucose biosensor that contains a perforated electrode embedded in a suspended diaphragm. This capacitive-based sensor contains no moving parts, and enables glucose diffusion and real-time monitoring. The experimental results indicate that this sensor can detect glucose solutions at physiological concentrations and possesses good reversibility and reliability. This sensor has a time constant to glucose concentration change at approximately 3 min, which is comparable to commercial systems. The sensor has potential applications in fully implantable CGM that require excellent long-term stability and reliability.

中文翻译：

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MEMS 介电亲和葡萄糖生物传感器


基于亲和力检测的连续血糖监测 (CGM) 传感器对于长期稳定的血糖管理是理想的。然而，大多数亲和传感器包含机械移动结构以及传感器驱动和信号读出的复杂设计，限制了它们在皮下植入式葡萄糖检测中的可靠性。我们之前已经演示了一种概念验证介电葡萄糖传感器，该传感器可以测量各种葡萄糖浓度下的预混合葡萄糖敏感聚合物溶液。该传感器设计简单，葡萄糖检测具有较高的特异性和准确性。但由于缺乏葡萄糖扩散通道，该装置无法实现实时体内监测。作为对该设备的重大改进，我们在本文中提出了一种完全植入式 MEMS 介电亲和葡萄糖生物传感器，其中包含嵌入悬浮隔膜中的穿孔电极。这种基于电容的传感器不包含移动部件，可以实现葡萄糖扩散和实时监测。实验结果表明，该传感器能够检测生理浓度的葡萄糖溶液，具有良好的可逆性和可靠性。该传感器的葡萄糖浓度变化时间常数约为 3 分钟，与商业系统相当。该传感器在需要出色的长期稳定性和可靠性的完全植入式 CGM 中具有潜在应用。