The purpose of this blinded study was to evaluate potential environmental toxicity in a cohort of neurotypical children (n = 28) living in a suburban area of north-central Texas in the United States (US) with a comparable age- and gender-matched cohort of neurotypical children (n = 28) living in a suburban area of southeastern France using urinary porphyrin testing: uroporphyrin (uP), heptacarboxyporphyrin (7cxP), hexacarboxyporphyrin (6cxP), pentacarboxyporphyrin (5cxP), precoproporphyrin (prcP), and coproporphyrin (cP). Results showed significantly elevated 6cxP, prcP (an atypical, mercury-specific porphyrin), and cP levels, and increasing trends in 5cxP levels, among neurotypical children in the USA compared to children in France. Data suggest that in US neurotypical children, there is a significantly increased body-burden of mercury (Hg) compared to the body-burden of Hg in the matched neurotypical children in France. The presence of lead contributing to the higher levels of cP also needs to be considered. Further, other factors including genetics can not be completely ruled out.

中文翻译：

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美国儿童的毒性生物标志物与法国类似人群的比较：一项测量尿卟啉的双盲研究


这项双盲研究的目的是评估一组生活在美国德克萨斯州中北部郊区的神经正常儿童 (n = 28) 的潜在环境毒性，并与年龄和性别匹配的可比队列进行比较居住在法国东南部郊区的神经型儿童 (n = 28) 使用尿卟啉检测：尿卟啉 (uP)、七羧基卟啉 (7cxP)、六羧基卟啉 (6cxP)、五羧基卟啉 (5cxP)、前粪卟啉 (prcP) 和粪卟啉 (cP) ）。结果显示，与法国儿童相比，美国神经正常儿童的 6cxP、prcP（一种非典型汞特异性卟啉）和 cP 水平显着升高，并且 5cxP 水平呈上升趋势。数据表明，与法国相应神经正常儿童的体内汞负荷相比，美国神经正常儿童的体内汞 (Hg) 负荷显着增加。还需要考虑铅的存在会导致较高的 cP 水平。此外，不能完全排除包括遗传在内的其他因素。