Food bioactives are known to prevent aging, cancer, and other diseases for an overall improved health of the consumer. Nanodelivery provides a means to control stability, solubility, and bioavailability, and also provides controlled release of food bioactives. There are two main types of nanodelivery systems, liquid and solid. Liquid nanodelivery systems include nanoemulsions, nanoliposomes, and nanopolymersomes. Solid nanodelivery systems include nanocrystals, lipid nanoparticles, and polymeric nanoparticles. Each type of nanodelivery system offers distinct benefits depending on the compatibility of nanoparticle properties with the properties of the bioactive and the desired application. Physicochemical properties of nanoparticles such as size, charge, hydrophobicity, and targeting molecules affect the absorption, distribution, metabolism, and excretion (ADME) of nanodelivery systems. The fate of the bioactive depends on its physicochemical properties and the location of its release. The safety of nanodelivery systems for use in food applications is largely unknown. Toxicological studies consisting of a combination of in silico, in vitro, and in vivo studies are needed to reveal the safety of nanodelivery systems for successful applications in food and agriculture.

中文翻译：

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用于食品的生物活性成分的纳米递送：递送系统的类型，性质及其对ADME曲线和纳米颗粒毒性的影响。

已知食品生物活性物质可防止衰老，癌症和其他疾病，从而全面改善消费者的健康状况。纳米递送提供了控制稳定性，溶解性和生物利用度的手段，还提供了食品生物活性物质的受控释放。纳米传递系统有两种主要类型，液体和固体。液体纳米递送系统包括纳米乳剂，纳米脂质体和纳米聚合物体。固体纳米递送系统包括纳米晶体，脂质纳米颗粒和聚合物纳米颗粒。每种类型的纳米传递系统都具有不同的优势，这取决于纳米粒子特性与生物活性剂的特性以及所需应用的兼容性。纳米粒子的物理化学性质（例如大小，电荷，疏水性和靶向分子）会影响吸收，分布，代谢，和排泄物（ADME）。生物活性物质的命运取决于其理化性质和释放位置。用于食品应用的纳米递送系统的安全性在很大程度上是未知的。需要毒理学研究，包括计算机模拟，体外和体内研究的组合，以揭示纳米递送系统在食品和农业中成功应用的安全性。