Bacterial adhesion and biofilm formation on surfaces raises health hazard issues in the medical environment. Previous studies of bacteria adhesion have focused on observations in their natural/native environments. Recently, surface science has contributed in advancing the understanding of bacterial adhesion by providing ideal platforms that attempt to mimic the bacteria's natural environments, whilst also enabling concurrent control, selectivity and spatial control of bacterial adhesion. In this review, we will look at techniques of how nanotechnology is used to control cell adhesion on a planar scale, in addition to describing the use of nanotools for cell micropatterning. Additionally, it will provide a general background of common methods for nanoscale modification enabling biologist unfamiliar with nanotechnology to enter the field.

表面上的细菌粘附和生物膜形成会引起医疗环境中的健康危害问题。以前对细菌粘附的研究集中在其自然/原生环境中的观察。最近，表面科学通过提供试图模拟细菌自然环境的理想平台，同时还能够同时控制、选择性和空间控制细菌粘附，从而促进了对细菌粘附的理解。在这篇综述中，除了描述使用纳米工具进行细胞微图案化外，我们还将研究如何使用纳米技术在平面尺度上控制细胞粘附的技术。此外，它将提供纳米级修饰常用方法的一般背景，使不熟悉纳米技术的生物学家能够进入该领域。