Ovarian cancer is one of the most lethal gynaecological cancers worldwide. However, the mechanisms underlying ovarian carcinogenesis are not well understood. The present study used immunostaining, western blotting and quantitative real-time PCR to demonstrate that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268-knockdown increased the viability, colony formation and growth of in vivo xenografts of ovarian carcinoma SKOV-3 cells, whereas SKOV-3 cell migration was inhibited. Furthermore, it was demonstrated that the knockdown of ZNF268 may increase SKOV-3 cell growth by promoting cell cycle progression. The findings suggest that ZNF268 is a novel protein involved in ovarian carcinogenesis and that it may aid in the understanding of the mechanisms of ovarian carcinogenesis.

中文翻译：

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ZNF268 的异常表达改变了卵巢癌细胞的生长和迁移。

卵巢癌是全球最致命的妇科癌症之一。然而，卵巢癌发生的潜在机制尚不清楚。本研究使用免疫染色、蛋白质印迹和定量实时 PCR 来证明 ZNF268 在人卵巢癌中过度表达。ZNF268 敲低增加了卵巢癌 SKOV-3 细胞体内异种移植物的活力、集落形成和生长，而 SKOV-3 细胞迁移受到抑制。此外，已证明敲低 ZNF268 可通过促进细胞周期进程来增加 SKOV-3 细胞生长。研究结果表明，ZNF268 是一种参与卵巢癌发生的新型蛋白质，它可能有助于理解卵巢癌发生的机制。