Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer-drug conjugates and nanoconjugates.

中文翻译：

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基于聚（丙交酯）和聚（丙交酯-共-乙交酯）的聚合物纳米药物。

小分子化疗药物通常具有不受欢迎的理化和药理特性，例如溶解度低、副作用严重和治疗指数窄。为了应对这些挑战，聚合物纳米药物给药技术已被常规采用，特别是使用可生物降解和生物相容性聚酯，如聚（丙交酯）（PLA）和聚（丙交酯-共-乙交酯）（PLGA）。在这里，我们回顾了 PLA 和 PLGA 的开发和使用，用于以聚合物-药物偶联物和纳米偶联物的形式递送化疗剂。