Improved methods for imaging and assessment of vascular defects are needed for directing treatment of cardiovascular pathologies. In this paper, we employ magnetomotive optical coherence tomography (MMOCT) as a platform both to detect and to measure the elasticity of blood clots. Detection is enabled through the use of rehydrated, lyophilized platelets loaded with superparamagnetic iron oxides (SPIO-RL platelets) that are functional infusion agents that adhere to sites of vascular endothelial damage. Evidence suggests that the sensitivity for detection is improved over threefold by magnetic interactions between SPIOs inside RL platelets. Using the same MMOCT system, we show how elastometry of simulated clots, using resonant acoustic spectroscopy, is correlated with the fibrin content of the clot. Both methods are based upon magnetic actuation and phase-sensitive optical monitoring of nanoscale displacements using MMOCT, underscoring its utility as a broad-based platform to detect and measure the molecular structure and composition of blood clots.

中文翻译：

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使用磁动光学相干断层扫描和标记血小板的血凝块成像和弹性测量

需要改进的血管缺陷成像和评估方法来指导心血管疾病的治疗。在本文中，我们采用磁动光学相干断层扫描 (MMOCT) 作为平台来检测和测量血凝块的弹性。通过使用装载有超顺磁性氧化铁（SPIO-RL 血小板）的再水化、冻干血小板（SPIO-RL 血小板）可以进行检测，这些血小板是粘附在血管内皮损伤部位的功能性输液剂。有证据表明，RL 血小板内的 SPIO 之间的磁相互作用将检测灵敏度提高了三倍以上。使用相同的 MMOCT 系统，我们展示了使用共振声波光谱法模拟凝块的弹性测量如何与凝块的纤维蛋白含量相关联。