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Investigation into the relationship between cord blood adiponectin levels and aortic intima media thickness in healthy, term neonates.
European Cytokine Network ( IF 2.2 ) Pub Date : 2013-07-05 , DOI: 10.1684/ecn.2013.0339
Dilek Sarici 1 , Mustafa Ali Akin , Selim Kurtoglu , Ali Yikilmaz , Sabahattin Muhtaroglu , Mehmet Adnan Ozturk , Tamer Gunes , S Umit Sarici
Affiliation  

INTRODUCTION Adiponectin has important anti-inflammatory and anti-atherogenic effects. Although adiponectin and atherosclerosis correlate inversely in children and adults, we have little information regarding this relationship in neonates. METHODS We measured cord blood adiponectin levels and abdominal aortic intima media thickness (aIMT) in 80 healthy, term neonates and investigated the relationship between adiponectin and total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglyceride, and their relationships to infant anthropometry and gender. RESULTS Mean birth weight, length, head circumference and aIMT values for male neonates were statistically significantly higher than those for female neonates. Adiponectin levels were not significantly different with respect to gender. In correlation analysis, the mean adiponectin level correlated positively with TC, HDL-C and LDL-C levels and birth weight, length and head circumference. There was no significant correlation between aIMT and any other parameters. CONCLUSION The cord blood adiponectin and aIMT values reported here for the first time, represent reference values in the early neonatal period. The positive correlations between adiponectin levels and birth weight, length and head circumference, and TC, HDL-C and LDL-C indicate that further studies are required to demonstrate the exact relationship and clinical importance of adiponectin metabolism during the neonatal period.

中文翻译:

健康足月新生儿脐血脂联素水平与主动脉内膜中层厚度之间关系的研究。

简介脂联素具有重要的抗炎和抗动脉粥样硬化作用。尽管脂联素与动脉粥样硬化在儿童和成人中呈负相关,但我们对新生儿中这种关系的了解很少。方法我们测量了80名健康足月新生儿的脐血脂联素水平和腹主动脉内膜中层厚度(aIMT),并调查了脂联素与总胆固醇(TC),LDL-胆固醇(LDL-C),HDL-胆固醇(HDL- C),甘油三酸酯及其与婴儿人体测量学和性别的关系。结果男性新生儿的平均出生体重,身长,头围和aIMT值在统计学上显着高于女性新生儿。脂联素水平在性别上无显着差异。在相关分析中,平均脂联素水平与TC,HDL-C和LDL-C水平以及出生体重,身长和头围呈正相关。aIMT与任何其他参数之间没有显着相关性。结论此处首次报道的脐带血脂联素和aIMT值代表了新生儿早期的参考值。脂联素水平与出生体重,身长和头围以及TC,HDL-C和LDL-C之间的正相关性表明,需要进行进一步的研究以证实新生儿时期脂联素代谢的确切关系和临床重要性。结论此处首次报道的脐带血脂联素和aIMT值代表了新生儿早期的参考值。脂联素水平与出生体重,身长和头围以及TC,HDL-C和LDL-C之间的正相关性表明,需要进行进一步的研究以证实新生儿时期脂联素代谢的确切关系和临床重要性。结论此处首次报道的脐带血脂联素和aIMT值代表了新生儿早期的参考值。脂联素水平与出生体重,身长和头围以及TC,HDL-C和LDL-C之间的正相关性表明,需要进行进一步的研究以证实新生儿时期脂联素代谢的确切关系和临床重要性。
更新日期:2019-11-01
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