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LC/MS applications in drug development.
Mass Spectrometry Reviews ( IF 6.9 ) Pub Date : 1999-11-24 , DOI: 10.1002/(sici)1098-2787(1999)18:3/4<187::aid-mas2>3.0.co;2-k
M S Lee 1 , E H Kerns
Affiliation  

The combination of high-performance liquid chromatography and mass spectrometry (LC/MS) has had a significant impact on drug development over the past decade. Continual improvements in LC/MS interface technologies combined with powerful features for structure analysis, qualitative and quantitative, have resulted in a widened scope of application. These improvements coincided with breakthroughs in combinatorial chemistry, molecular biology, and an overall industry trend of accelerated development. New technologies have created a situation where the rate of sample generation far exceeds the rate of sample analysis. As a result, new paradigms for the analysis of drugs and related substances have been developed. The growth in LC/MS applications has been extensive, with retention time and molecular weight emerging as essential analytical features from drug target to product. LC/MS-based methodologies that involve automation, predictive or surrogate models, and open access systems have become a permanent fixture in the drug development landscape. An iterative cycle of "what is it?" and "how much is there?" continues to fuel the tremendous growth of LC/MS in the pharmaceutical industry. During this time, LC/MS has become widely accepted as an integral part of the drug development process. This review describes the utility of LC/MS techniques for accelerated drug development and provides a perspective on the significant changes in strategies for pharmaceutical analysis. Future applications of LC/MS technologies for accelerated drug development and emerging industry trends are also discussed.

中文翻译:

LC / MS在药物开发中的应用。

在过去十年中,高效液相色谱法和质谱分析法(LC / MS)的结合对药物开发产生了重大影响。LC / MS接口技术的不断改进,结合强大的结构分析,定性和定量功能,导致了广泛的应用范围。这些改进与组合化学,分子生物学的突破以及整个行业加速发展的趋势相吻合。新技术造成了这样一种情况,即样品的产生速度远远超过了样品分析的速度。结果,开发了用于药物和相关物质分析的新范例。LC / MS应用的增长迅速,保留时间和分子量已成为从药物靶标到产品的基本分析特征。涉及自动化,预测或替代模型以及开放获取系统的基于LC / MS的方法论已成为药物开发领域的永久性手段。“什么是迭代”的迭代周期。和“多少钱?” 继续推动制药行业LC / MS的巨大增长。在此期间,LC / MS已被广泛接受为药物开发过程的组成部分。这篇综述描述了LC / MS技术在加速药物开发中的实用性,并为药物分析策略的重大变化提供了一个视角。还讨论了LC / MS技术在加速药物开发和新兴行业趋势方面的未来应用。
更新日期:2019-11-01
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