Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.

中文翻译：

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一种多物理场建模方法，用于开发带有收缩带的右心室肺动脉瓣置换手术程序，以提高心室射血分数

修复法洛四联症的患者占晚发性右心室 (RV) 衰竭的大多数病例。提出了一种在右心室放置松紧带的新外科手术，以改善通过射血分数测量的 RV 功能。开发了一种多物理场建模方法，将心脏磁共振成像、建模、组织工程和机械测试相结合，以证明新手术程序的可行性。我们的建模结果表明，新的外科手术有可能将右心室射血分数提高 2-7%，这与最近发表的治疗 LV 心力衰竭的药物试验相比具有优势。