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Charge derivatization of peptides for analysis by mass spectrometry.
Mass Spectrometry Reviews ( IF 6.9 ) Pub Date : 1999-05-04 , DOI: 10.1002/(sici)1098-2787(1998)17:4<255::aid-mas1>3.0.co;2-4
K D Roth 1 , Z H Huang , N Sadagopan , J T Watson
Affiliation  

The analysis of peptide derivatives by fast atom bombardment, liquid secondary-ionization mass spectrometry, plasma desorption, electrospray ionization, and matrix-assisted laser desorption/ionization is reviewed. The fragmentation patterns of peptides and of charge-derivatized peptides are compared, and the proposed fragment ion structures are summarized. A variety of derivatization approaches and the distinguishing features of mass spectra produced from these derivatives are described. The most promising derivatization approaches are evaluated, and the strengths and limitations of these approaches are discussed.

中文翻译:

肽的电荷衍生化,通过质谱分析。

综述了通过快速原子轰击,液相二次电离质谱,等离子体解吸,电喷雾电离和基质辅助激光解吸/电离对肽衍生物的分析。比较了肽和电荷衍生的肽的片段化模式,并总结了所提出的片段离子结构。描述了各种衍生化方法以及由这些衍生物产生的质谱的显着特征。对最有希望的衍生化方法进行了评估,并讨论了这些方法的优势和局限性。
更新日期:2019-11-01
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