To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 serum samples from 6 cases with GPP during the course of the disease. Serum levels of IL-4, IL-8, CXCL1 and CCL3 were positively correlated with the severity scores of GPP, white blood cell counts and serum C-reactive protein levels. Serum levels of IL-1β, IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN-γ and VEGF showed strong positive correlations (r > 0.4, p < 0.01) with all those 3 clinical markers. Of those, IL-10 and IL-22 were significantly decreased after treatment in parallel with the GPP score and therefore those two serum cytokines might be useful to evaluate the efficacy of treatment for GPP.

中文翻译：

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血清细胞因子与全身脓疱型银屑病的疾病严重程度相关。

为了表征反映全身性脓疱型银屑病 (GPP) 严重程度的血清生物标志物，我们在疾病过程中测量了来自 6 例 GPP 患者的 39 份血清样本中的多种细胞因子/趋化因子水平。血清IL-4、IL-8、CXCL1和CCL3水平与GPP严重程度评分、白细胞计数和血清C反应蛋白水平呈正相关。IL- 1β、IL-1ra、IL-6、IL-10、IL-12p70、IL-18、IL-22、IFN- γ和VEGF的血清水平呈强正相关（r >0.4，p< 0.01) 与所有这 3 个临床标志物。其中，IL-10 和 IL-22 在治疗后与 GPP 评分平行显着降低，因此这两种血清细胞因子可能有助于评估 GPP 治疗的疗效。