A facile method for synthesis of poly ethylene glycol (PEG)-armed hyperbranched polyoxetanes is presented along with characterization and use in drug delivery. A series of hyperbranched polyoxetanes with multiple PEG arms were synthesized via a one-pot cationic ring-opening polymerization of 3-ethyl-3-hydroxymethyl oxetane (EHMO) and its PEGylated derivative (EPMO), in which the feed mass ratio of EHMO to EPMO was 98:2, 96:4, 74:26, or 17:83. Characterization methods included nuclear magnetic resonance, dynamic light scattering, Fourier transform infrared, differential scanning calorimetry, and scanning electron microscopy. Toxicity of the synthesized polymers to human dermal fibroblasts was evaluated using the MTT assay. Formulation into particles was carried out to encapsulate the anticancer drug camptothecin using the single oil-in-water solvent evaporation method. The resulting drug encapsulated particles were evaluated for antitumor activity using HN12 cells.

中文翻译：

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用于抗癌药物递送的聚（乙二醇）臂超支化聚氧杂环丁烷

提出了一种合成聚乙二醇 (PEG) 武装的超支化聚氧杂环丁烷的简便方法，以及在药物递送中的表征和使用。通过 3-乙基-3-羟甲基氧杂环丁烷 (EHMO) 及其聚乙二醇化衍生物 (EPMO) 的一锅阳离子开环聚合反应合成了一系列具有多个 PEG 臂的超支化聚氧杂环丁烷，其中 EHMO 与EPMO 为 98:2、96:4、74:26 或 17:83。表征方法包括核磁共振、动态光散射、傅里叶变换红外、差示扫描量热法和扫描电子显微镜。合成的聚合物对人真皮成纤维细胞的毒性使用 MTT 测定进行评估。使用单一水包油溶剂蒸发法将抗癌药物喜树碱制成颗粒以封装抗癌药物喜树碱。使用 HN12 细胞评估所得药物包封颗粒的抗肿瘤活性。