We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.

中文翻译：

---

Aurora A 过表达和 pVHL 表达降低与肾癌预后不良相关。

我们研究了肿瘤抑制蛋白 pVHL 以及癌蛋白 Aurora A 激酶在肾癌中的表达和定位。使用免疫组织化学评估 Aurora A 激酶和 pVHL 蛋白状态。Aurora A 表达与 Fuhrman 分级和 TNM 分期相关，而 pVHL 表达与包膜破裂和 TNM 分期相关。与非恶性组织相比，恶性组织中的极光 A 激酶表达增加。并且从邻近的健康组织到肿瘤组织的 pVHL 表达降低。根据TNM分期，两种相反的肿瘤谱显示出显着的分布差异。