Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis. The purpose of the present study was to examine the possible correlation between serum cytokine concentrations, thyroid hormones (FT4 and TSH) and auto-antibodies (Tg and TPO), and their usefulness in discriminating between different thyroid conditions. In this study, we investigated serum from 115 patients affected with a variety of thyroid conditions (44 Graves' disease, 17 Hashimoto's thyroiditis, 11 atrophic thyroiditis, 28 thyroid nodular goitre and 15 papillary thyroid cancer), and 30 controls. Levels of 17 cytokines in serum samples were measured simultaneously using a multiplexed human cytokine assay. Thyroid hormones and auto-antibodies were measured using ELISA. Our study showed that IL-1β serum concentrations allow the discrimination between atrophic thyroiditis and papillary thyroid cancer groups (p = 0.027).

中文翻译：

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IL-1β是区分甲状腺癌和萎缩性甲状腺炎的潜在因素。

细胞因子与其他可溶性因子（激素，抗体...）之间的相互作用可在甲状腺发病机理的发展中发挥重要作用。本研究的目的是检查血清细胞因子浓度，甲状腺激素（FT4和TSH）和自身抗体（Tg和TPO）之间的可能相关性，以及它们在区分不同甲状腺疾病中的有用性。在这项研究中，我们调查了115位患有各种甲状腺疾病（44例格雷夫斯病，17例桥本氏甲状腺炎，11例萎缩性甲状腺炎，28例甲状腺结节性甲状腺肿和15例甲状腺乳头状癌）的患者的血清和30例对照。使用多重人细胞因子测定法同时测量血清样品中17种细胞因子的水平。使用ELISA测量甲状腺激素和自身抗体。