We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia then a left corticobasal syndrome (CBS). Neuroimaging (CT, MRI and FDG-PET) unequivocally showed progressive right hemispheric atrophy and hypometabolism. This particular evolution first confirms that PAOS is a phenotype of probable corticobasal degeneration (CBD). More importantly, this case underpins the neural organisation of motor planning processing in relation with speech, as well as graphic and limb praxis impairments, and constitutes a rare example of crossed-PAOS.

中文翻译：

---

渐进性交叉性言语障碍是可能的皮质基底节变性的第一个表现。

我们介绍了一名 64 岁右利手女性的纵向神经语言学、神经心理学和神经学随访，该女性出现进行性言语失用 (PAOS)，然后是外周失语症，然后是左皮质基底节综合征 (CBS)。神经影像学（CT、MRI 和 FDG-PET）明确显示进行性右半球萎缩和低代谢。这种特殊的进化首先证实了 PAOS 是一种可能的皮质基底节变性 (CBD) 的表型。更重要的是，这个案例支持了与语言相关的运动规划处理的神经组织，以及图形和肢体实践障碍，并构成了交叉 PAOS 的罕见例子。