We report patterns of dysgraphia in participants with primary progressive aphasia that can be explained by assuming disruption of one or more cognitive processes or representations in the complex process of spelling. These patterns are compared to those described in participants with focal lesions (stroke). Using structural imaging techniques, we found that damage to the left extrasylvian regions, including the uncinate, inferior fronto-occipital fasciculus, and sagittal stratum (including geniculostriate pathway and inferior longitudinal fasciculus), as well as other deep white and grey matter structures, was significantly associated with impairments in access to orthographic word forms and semantics (with reliance on phonology-to-orthography to produce a plausible spelling in the spelling to dictation task). These results contribute not only to our understanding of the patterns of dysgraphia following acquired brain damage but also the neural substrates underlying spelling.

中文翻译：

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与中风后失语症相比，原发性进行性失语症的书写困难模式。

我们报告了原发性进行性失语症参与者的书写障碍模式，这可以通过假设复杂拼写过程中一个或多个认知过程或表征的中断来解释。这些模式与局灶性病变（中风）参与者中描述的模式进行了比较。使用结构成像技术，我们发现左侧外侧裂区，包括钩状、下额枕束和矢状层（包括膝纹状通路和下纵束）以及其他深部白质和灰质结构的损伤是与使用正字法词形和语义的障碍显着相关（在拼写到听写任务中依赖音韵到正字法来产生似是而非的拼写）。