Terahertz pulsed spectroscopy was used to qualitatively detect ciprofloxacin hydrochloride monohydrate (CPFX·HCl·H₂O) in tablets, and terahertz pulsed imaging (TPI) was used to scrutinize not only the coating state but also the density distribution of tablets produced by several manufacturers. TPI was also used to evaluate distinguishability among these tablets. The same waveform, which is a unique terahertz absorption spectrum derived from pure CPFX·HCl·H₂O, was observed in all of the crushed tablets and in pure CPFX·HCl·H₂O. TPI can provide information about the physical states of coated tablets. Information about the uniformity of parameters such as a coating thickness and density can be obtained. In this study, the authors investigated the coating thickness distributions of film-coated CPFX·HCl·H₂O from four different manufacturers. Unique terahertz images of the density distributions in these commercial tablets were obtained. Moreover, B-scan (depth) images show the status of the coating layer in each tablet and the density map inside the tablets. These features would reflect differences resulting from different tablet-manufacturing processes.

中文翻译：

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通过太赫兹脉冲光谱和成像对商业盐酸环丙沙​​星一水合物片剂的包衣和密度分布进行分析。

采用太赫兹脉冲光谱法对片剂中的盐酸环丙沙​​星一水合物(CPFX·HCl·H ₂ O)进行定性检测，利用太赫兹脉冲成像(TPI)对多家厂商生产的片剂进行包衣状态和密度分布检测. TPI 还用于评估这些片剂之间的可区分性。在所有压碎的片剂和纯 CPFX·HCl·H ₂中都观察到相同的波形，即源自纯 CPFX·HCl·H ₂ O的独特太赫兹吸收光谱O. TPI 可以提供有关包衣片剂物理状态的信息。可以获得有关参数均匀性的信息，例如涂层厚度和密度。在这项研究中，作者研究了来自四个不同制造商的薄膜包衣 CPFX·HCl·H ₂ O的涂层厚度分布。获得了这些商业片剂中密度分布的独特太赫兹图像。此外，B 扫描（深度）图像显示每个片剂中包衣层的状态和片剂内部的密度图。这些特征将反映不同片剂制造工艺导致的差异。