Scale-up microsphere fabrication with controllable microsphere size has always been an exciting manufacturing challenge. The objective of this study is to experimentally study the effects of material properties and operating conditions on the formability of alginate microspheres and the microsphere size during drop-on-demand (DOD)-based single nozzle jetting. Alginate microspheres have been fabricated using bipolar wave-based DOD jetting, and its formability and size have been studied especially as a function of sodium alginate and calcium chloride concentrations, voltage rise/fall times, dwell and echo times, excitation voltage amplitudes, and frequency. It is found that (1) the formability is sensitive to the sodium alginate and calcium chloride concentrations, dwell and echo voltages, and voltage dwell time; and the formability decreases with the sodium alginate concentration but increases with the calcium chloride concentration, dwell and echo voltages, and voltage dwell time; (2) the size is not sensitive to the sodium alginate and calcium chloride concentrations but increases first with the dwell time and then decreases; and (3) the size increases with the dwell and absolute echo voltage amplitudes.

具有可控微球尺寸的放大微球制造一直是令人兴奋的制造挑战。本研究的目的是通过实验研究材料特性和操作条件对基于按需滴落 (DOD) 的单喷嘴喷射过程中海藻酸盐微球的可成形性和微球尺寸的影响。海藻酸盐微球已使用基于双极波的 DOD 喷射制造，其成形性和尺寸已被研究，特别是作为海藻酸钠和氯化钙浓度、电压上升/下降时间、驻留和回波时间、激励电压幅度和频率的函数. 发现(1)成形性对海藻酸钠和氯化钙浓度、驻留电压和回波电压以及电压驻留时间敏感；成型性随海藻酸钠浓度的增加而降低，但随氯化钙浓度、驻留电压和回波电压以及电压驻留时间的增加而增加；(2)粒径对海藻酸钠和氯化钙浓度不敏感，但随停留时间的增加先增大后减小；(3) 尺寸随着驻留和绝对回波电压幅度而增加。