Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case-control datasets of SNPs variants located at 1p13.1, 2q33.1, 10q11.1, 9p21, and 21q22. We observed a small significant risk associated of the SNP rs10757274 with CAD in the PROCAGENE study. Besides, the multilocus combination rs10757274 and rs1333048 gave a near significant result. We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant. Independent replication studies in other populations are needed to unequivocally confirm the association.

中文翻译：

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在加那利群岛人群的病例对照研究中从 GWA 获得的与心血管疾病易感性相关的相关 SNP 的复制。

最近的全基因组单核苷酸多态性 (SNP) 关联研究 (GWAS) 发现了许多与冠状动脉疾病 (CAD) 和心肌梗塞 (MI) 显着相关的 SNP。我们在位于 1p13.1、2q33.1、10q11.1、9p21 和 21q22 的 SNP 变体的病例对照数据集中测试了先前描述的与 CAD 关联的复制情况。我们在 PROCAGENE 研究中观察到 SNP rs10757274 与 CAD 存在较小的显着风险相关。此外，多位点组合rs10757274和rs1333048给出了接近显着的结果。我们证实，SNP rs10757274 在 PROCAGENE 研究中显示与 CAD 相关，尽管应用 Bonferroni 校正后不再显着。需要在其他人群中进行独立的复制研究来明确证实这种关联。