A multitude of host genetic factors plays a crucial role in susceptibility to HIV-1 infection and progression to AIDS, which is highly variable among individuals and populations. This review focuses on the chemokine-receptor and chemokine genes, which were extensively studied because of their role as HIV co-receptor or co-receptor competitor and influences the susceptibility to HIV-1 infection and progression to AIDS in HIV-1 infected individuals.

中文翻译：

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趋化因子和趋化因子受体对 HIV-1 感染和进展为艾滋病的易感性。

多种宿主遗传因素在对 HIV-1 感染的易感性和向 AIDS 的发展方面起着至关重要的作用，这在个体和人群之间变化很大。本综述重点关注趋化因子受体和趋化因子基因，由于它们作为 HIV 共同受体或共同受体竞争者的作用而被广泛研究，并影响 HIV-1 感染个体对 HIV-1 感染的易感性和向 AIDS 的进展。