The objective of our paper was to determine the effects of composite formulation on the compressive modulus and ultimate strength of a biodegradable, in situ polymerizable poly(propylene fumarate) (PPF) and bone fiber scaffold. The following parameters were investigated: the incorporation of bone fibers (either mineralized or demineralized), PPF molecular weight, N-vinyl pyrrolidinone (NVP) crosslinker amount, benzoyl peroxide (BP) initiator amount, and sodium chloride porogen amount. Eight formulations were chosen based on a resolution III two-level fractional factorial design. The compressive modulus and ultimate strength of these formulations were measured on a materials testing machine. Absolute values for compressive modulus varied from 21.3 to 271 MPa and 2.8 to 358 MPa for dry and wet samples, respectively. The ultimate strength of the crosslinked composites varied from 2.1 to 20.3 MPa for dry samples and from 0.4 to 16.6 MPa for wet samples. Main effects of each parameter on the measured property were calculated. The incorporation of mineralized bone fibers and an increase in PPF molecular weight resulted in higher compressive modulus and ultimate strength. Both mechanical properties also increased as the amount of benzoyl peroxide increased or the NVP amount decreased in the formulation. Sodium chloride had a dominating effect on the increase of mechanical properties in dry samples but showed little effects in wet samples. Demineralization of bone fibers led to a decrease in the compressive modulus and ultimate strength. Our results suggest that bone fibers are appropriate as structural enforcement components in PPF scaffolds. The desired orthopaedic PPF scaffold might be obtained by changing a variety of composite formulation parameters.

中文翻译：

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复合材料配方对生物可降解聚（富马酸丙二醇酯）/骨纤维支架力学性能的影响。

我们论文的目的是确定复合材料配方对可生物降解的原位可聚合聚富马酸丙酯 (PPF) 和骨纤维支架的压缩模量和极限强度的影响。研究了以下参数：骨纤维的掺入（矿化或脱矿质）、PPF 分子量、N-乙烯基吡咯烷酮 (NVP) 交联剂用量、过氧化苯甲酰 (BP) 引发剂用量和氯化钠致孔剂用量。基于分辨率 III 两水平部分因子设计选择了八种配方。在材料试验机上测量这些配方的压缩模量和极限强度。对于干和湿样品，压缩模量的绝对值分别从 21.3 到 271 MPa 和 2.8 到 358 MPa 不等。干样品的交联复合材料的极限强度为 2.1 至 20.3 MPa，湿样品的极限强度为 0.4 至 16.6 MPa。计算每个参数对测量特性的主要影响。矿化骨纤维的加入和 PPF 分子量的增加导致更高的压缩模量和极限强度。随着配方中过氧化苯甲酰量的增加或 NVP 量的减少，两种机械性能也增加。氯化钠对干燥样品的机械性能增加有主要影响，但对湿样品的影响很小。骨纤维的脱矿质导致压缩模量和极限强度降低。我们的研究结果表明，骨纤维适合作为 PPF 支架中的结构强化成分。