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Simulation of Drug Uptake in a Two Compartmental Fractional Model for a Biological System.
Communications in Nonlinear Science and Numerical Simulation ( IF 3.4 ) Pub Date : 2011-02-18 , DOI: 10.1016/j.cnsns.2011.02.012
Ivo Petráš 1 , Richard L Magin
Affiliation  

This paper presents a very effective numerical method for the solution of the two-compartmental pharmacokinetic model for oral drug administration. This model consists of a set of two fractional order differential equations which connect the two compartments. The first compartment represents the gut while the second compartment corresponds to the drug concentration in the target tissue. For ease of computation, the numerical solution is also created as a Matlab function.



中文翻译:

在生物系统的两室分数模型中模拟药物摄取。

本文提出了一种非常有效的数值方法来求解口服给药的二室药代动力学模型。该模型由一组连接两个隔室的两个分数阶微分方程组成。第一个隔室代表肠道,而第二个隔室对应于靶组织中的药物浓度。为便于计算,数值解也创建为 Matlab 函数。

更新日期:2011-02-18
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