Abstract The temporal response of pulsed nano-electrospray ionization mass spectrometry (nano-ESI-MS) was studied and its influence on ion formation and detection was characterized. Rise and decay times for the mass resolved ion current were determined to be 20 ± 3 msec and 61 ± 5 msec, respectively, which led to a maximum pulse rate of 12 Hz. Pulsed nano-ESI operation was demonstrated from a multi-sprayer source controlled by a high voltage pulsing circuit constructed in-house. The desired source mode of operation (e.g. pulsing or continuous) can be realized solely by controlling the voltage applied to each sprayer.

中文翻译：

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脉冲纳米电喷雾电离：时间响应的表征和扩展入口毛细管的实施

摘要 研究了脉冲纳电喷雾电离质谱（nano-ESI-MS）的时间响应，并表征了其对离子形成和检测的影响。质量分辨离子电流的上升和衰减时间分别确定为 20 ± 3 毫秒和 61 ± 5 毫秒，这导致最大脉冲频率为 12 Hz。脉冲纳米 ESI 操作通过由内部构建的高压脉冲电路控制的多喷雾器源进行演示。所需的源操作模式（例如脉冲或连续）可以单独通过控制施加到每个喷雾器的电压来实现。