Nonenzymatic template-directed copying of RNA sequences rich in cytidylic acid using nucleoside 5'-(2-methylimidazol-1-yl phosphates) as substrates is substantially more efficient than the copying of corresponding DNA sequences. However, many sequences cannot be copied, and the prospect of replication in this system is remote, even for RNA. Surprisingly, wobble-pairing leads to much more efficient incorporation of G opposite U on RNA templates than of G opposite T on DNA templates.

中文翻译：

---

模板指导合成中RNA与DNA的比较。

使用核苷5'-（2-甲基咪唑-1-基磷酸酯）作为底物，对富含胞苷酸的RNA序列进行非酶模板定向复制比复制相应的DNA序列效率更高。然而，许多序列不能被复制，并且即使对于RNA，在该系统中复制的前景也很遥远。令人惊讶地，摆动配对导致RNA模板上与U相反的G的掺入比DNA模板上与T相反的G的掺入更有效。