Although aging causes functional declines in cognition, the molecular mechanism underlying these declines remains largely unknown. Recently, the spindle checkpoint kinase budding uninhibited by benzimidazole-related 1 (BubR1) has emerged as a key determinant for age-related pathology in various tissues including brain. However, the neurobehavioral impact of BubR1 has not been explored. In this study, we investigated the role of BubR1 in behavioral function.

中文翻译：

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BubR1功能不足会损害小鼠的情感行为和记忆功能。

尽管衰老会导致认知功能下降，但导致这些下降的分子机制仍然未知。最近，不受苯并咪唑相关1（BubR1）抑制的纺锤体检查点激酶已经出现，成为包括大脑在内的各种组织中与年龄相关的病理的关键决定因素。但是，尚未探讨BubR1的神经行为影响。在这项研究中，我们调查了BubR1在行为功能中的作用。