We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to self-assemble into nanoparticles (NPs) in water with size range from ∼21-32 nm to 55-68 nm to 95-106 nm. Excepted for size, these TPE-buried amphiphile fabricated NPs hold identical physical properties such as spherical shape, surface charge, and luminescent properties, and moreover, after covalent capture of the acrylate hydrophilic heads, the resulting cross-linked NPs (cNPs I-III) own excellent in vivo stability, which thus would be an ideal platform for investigating the size effects on tumor accumulation and penetration.

中文翻译：

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助溶剂极性控制的四苯基乙烯埋入式两亲物的自组装，可调节大小的肿瘤。

我们报告说，助溶剂的极性可以精确控制TPE埋入的两亲物1在水中的自组装成纳米颗粒（NPs），尺寸范围为〜21-32 nm至55-68 nm至95-106 nm。除了尺寸外，这些用TPE埋藏的两亲物制造的NP具有相同的物理特性，例如球形，表面电荷和发光特性，而且，在丙烯酸酯亲水性头被共价捕获后，所得的交联NP（cNPs I-III ）具有出色的体内稳定性，因此将成为研究肿瘤大小对肿瘤蓄积和穿透的理想平台。