Chronic atrophic gastritis is a generally asymptomatic condition of great importance because it develops into gastric cancer in a number of patients. It is described as an atrophy of the gastric mucosa. There are two types of atrophic gastritis: a gastric body predominant type in patients with infection of Helicobacter pylori, and an autoimmune type, limited to the gastric body and fundus. The autoimmune type is quite rare and affects people of all ethnicities. Globally, H. pylori infection is very common and is considered a class I carcinogen due to the large number of patients who subsequently develop gastric cancer. The pathogenesis of the autoimmune type involves an antibody-mediated loss of parietal cells resulting in achlorhydria and an antibody-mediated loss of intrinsic factor that causes pernicious anemia. The diagnosis of H. pylori infection is based on endoscopy and culture of the organisms. Patients with atrophic gastritis as well as H. pylori infection should be treated with antibiotics to eradicate the organism. Patients with the autoimmune type need to be evaluated for anemia, and if present, treated with vitamin B12.

中文翻译：

---

慢性萎缩性胃炎：综述。

慢性萎缩性胃炎通常是非常重要的无症状疾病，因为它在许多患者中会发展成胃癌。它被描述为胃粘膜萎缩。萎缩性胃炎有两种类型：幽门螺杆菌感染患者以胃体为主，而仅限于胃体和眼底的自身免疫型。自身免疫类型非常罕见，会影响所有种族的人。在全球范围内，幽门螺杆菌感染非常普遍，由于大量随后发生胃癌的患者而被认为是I类致癌物。自身免疫型的发病机制涉及抗体介导的壁细胞损失，从而导致胃酸缺乏症和抗体介导的内在因素的丧失，后者导致恶性贫血。H的诊断 幽门螺杆菌感染是基于生物的内窥镜检查和培养。萎缩性胃炎以及幽门螺杆菌感染的患者应使用抗生素治疗，以根除该细菌。需要对自身免疫型患者进行贫血评估，如果存在贫血，应使用维生素B12治疗。